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NONA group

New paper about ultrasensitive biosensors based on virus-like particles and plasmonic surface lattice resonance

Date: 14.01.2025

The manuscript on our work done in collaboration with group of Professor Mikołaj Lewandowski from University of Adam Mickiewicz in Poznań is just online!

Abstract
Plasmonic surface lattice resonance (SLR) is a phenomenon in which individual localized surface plasmon resonances (LSPRs) excited in periodically-arranged plasmonic nanoparticles couple through the interaction with the propagating diffracted incident light. The SLR optical absorption peak is by at least one order of magnitude more intense than the LSPR one, making SLR superior for applications in which LSPR is commonly used. Recently, we have developed a route for the fabrication of spherical virus-like particles (VLPs) with plasmonic cores and protein coronas, where the LSPR in the cores amplifies vibrational Raman signals originating from protein-antibody bonding [ACS Synth. Biol. 12 (2023) 2320]. The particles show great potential in biodetection, however, the intensity of the signals recorded in solution is not strong enough to detect antibodies at very low concentrations. Here, we show that by ordering the VLPs in periodic nanoarrays exhibiting SLR amplifies the signals by two orders of magnitude, revealing superior potential of VLP-SLR arrays in ultrasensitive biodetection.


You can read it here: https://doi.org/10.1016/j.bios.2025.117143

Congratulations to all co-authors!

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